Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease
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چکیده
منابع مشابه
Peripheral Eosinophilia and History of Allergy in Patients with Coronary Artery Disease
Background: Coronary artery diseases (CAD) is the most common cause of death in the developing counteries. Atherosclerosis is the leading cause of CAD. A number of studies have shown that total leukocyte count is a risk factor for CAD but there is little information on the role of eosinophilia and allergy. The aim of this study was to determine the relationship between eosinophilia and histor...
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OBJECTIVES We aimed to determine whether intracoronary supplementation with nitric oxide (NO) synthase co-factor tetrahydrobiopterin (BH4) improves NO-dependent coronary microvascular dilation in patients with coronary risk factors but no significant organic stenosis. BACKGROUND Impaired coronary microvascular dilator reserve attributable to endothelial dysfunction plays an important role in th...
متن کاملSerum Eicosapentaenoic and Arachidonic Acids Concentration and Cognitive Function in Patients With Coronary Artery Disease
Introduction: Recent studies have shown that Polyunsaturated Fatty Acids (PUFAs), including Eicosapentaenoic Acid (EPA), and Arachidonic Acid (AA), are associated with cognitive functions in patients with Coronary Artery Disease (CAD). Nevertheless, controversial results have been reported, too. The current study aimed to clarify the association of serum EPA and AA levels with cognitive decline...
متن کاملEvaluation of iron status in patients with coronary artery disease
Background: Iron can causes lipid peroxidation in vivo and in vitro. Iron promotes myocardial injury in experimental animals. Low Density Lipoprotein (LDL) oxidation by oxidants including iron have a central role in atherosclerotic process. By this means, evaluation of serum iron in patients with coronary artery disease (CAD) has a significant importance. Materials and Methods: In this cross s...
متن کاملCoronary Heart Disease Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus
Background—Endothelial dysfunction plays an important role in the early development of atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased expression and activity of arginase, metabolizing the nitric oxide substrate L-arginine, may result in reduced production of nitric oxide and thereby endothelial dysfunction. We hypothesized that inhibition of arginase activity ...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2005
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2005.06.004